Mario Raviglione, Mukund Uplekar, Diana Weil, Teresa Kasaeva, Email the author Mukund Uplekar,
Published: 15 November 2017
The fact that more
than 10 million people fall ill with tuberculosis annually, and that
5000 die of it every day, including about 1000 because of HIV-associated
infection, speaks to the gravity of the global problem of tuberculosis.
Tuberculosis has many other dubious distinctions that merit attention:
it is one of the oldest diseases known to mankind and yet one of the top
ten global causes of death today, the top infectious cause of death
worldwide, the top killer of people with HIV infection, and a top cause
of death due to antimicrobial-resistant infections.1 Bearing this in mind, investing in the fight against tuberculosis is a “no brainer” development target, according to The Economist and the Copenhagen Consensus, given the benefits gained per dollar spent.2
Countries have committed, as part of the WHO's End TB Strategy and the
Sustainable Development Goals (SDGs), to ending the tuberculosis
epidemic by 2030.3, 4
The Stop TB Partnership's Global Plan to End TB, 2016–2020, laid out
the estimated financing needs for the first 5 years in implementing the
End TB Strategy.5 Yet in 2016, WHO reported that the world was failing to accelerate actions to meet the first milestones towards these targets.
At
the end of 2016, there finally seemed to be a swell of political
recognition of the problem, in view of the dire facts and growing vocal
demand from people affected by tuberculosis. First, WHO and the Russian
Federation decided to hold the very first WHO Global Ministerial
Conference on Ending TB (Nov 16–17, 2017) to stimulate action and
commitments. Second, the UN General Assembly announced the first ever
high-level meeting on the fight against tuberculosis in 2018.6
Third, in July, 2017, the G20 leaders recognised that acting on
priority pathogens, including tuberculosis, is a crucial part of global
efforts to combat antimicrobial resistance. Fourth, at the meeting of
the Brazil, Russia, India, China, and South Africa (BRICS) leaders in
September, 2017, these countries committed to combat tuberculosis
together, including advancing tuberculosis research. There is a strong
foundation on which this work is building: between 2000 and 2016,
tuberculosis treatment alone saved 53 million lives, including those of
people with HIV.
However, there are profound weaknesses
that inhibit acceleration of these movements. Weak health systems are
still far from providing universal coverage without financial hardship
for high-quality services, including use of new tools for tuberculosis
care and, more urgently, for multidrug-resistant tuberculosis, leaving
more than a third of all tuberculosis cases unreported. There is a
dearth of innovative approaches that enable reaching the high-risk
groups and susceptible populations. There is also a paucity of new and
better tools for tuberculosis care and prevention: point-of-care
diagnostics, new drugs, shorter and better treatment regimens, and safe
and effective tuberculosis vaccines. Finally, there is no truly
multisectoral tuberculosis response, which is essential to address the
drivers and determinants of the epidemic.
The latest
global burden of disease assessment measuring progress on health-related
SDGs concludes that tuberculosis is one of the health challenges for
which dramatic acceleration of progress is most needed.7
Such urgent acceleration of efforts and investments is possible
considering recent changes in global political economy: half of the
countries with high tuberculosis incidence that were classified as
low-income in 2000 are now in the middle-income category, and more
countries are expected to join by 2020.8
The five BRICS countries bear about 45% of the world's burden of
tuberculosis and more than 60% of the multidrug-resistant tuberculosis
burden.9
BRICS and other middle-income countries with growing economies could
ensure that domestic resources are mobilised and sustained to finance
their responses to tuberculosis. Ending the global tuberculosis epidemic
also requires parallel and substantial progress on health-related and
other SDGs. Within the health-related SDG3 targets, universal health
coverage and controlling the epidemics of HIV, diabetes, alcohol-use
disorders, and tobacco smoking need to be addressed. The drivers and
determinants of the tuberculosis epidemic and the direct risk factors
for tuberculosis will, however, need action on other, non-health-related
SDGs. These include addressing poverty and social protection (SDG1),
hunger (SDG2), indoor air pollution (SDG7), working and living
conditions (SDG8), inequalities (SDG10), and urban slums (SDG11). The
triple feat of reaching more people who need care today, broadening
actions to prevent tuberculosis, and investing in research to deliver
innovations means that leaders from within and beyond government need to
act in a coordinated fashion.
There are at least four
clear expectations from the health ministers and all partners gathering
at the ministerial conference in Moscow. First, speed up universal
coverage of care and prevention for tuberculosis, HIV-associated
tuberculosis, and multidrug-resistant tuberculosis in the context of the
global agendas of antimicrobial resistance, health security, and SDGs,
while ensuring that equity, ethics, and human rights are recognised as
urgent concerns and are protected and promoted. Second, enable
sufficient and sustained financing for the full response from
strengthened domestic and external sources. Third, urgently increase
coordinated investments in research and innovations. Finally, and most
importantly, to drive real action built on written commitments, a
multisectoral accountability framework needs to be prepared and adhered
to. This framework needs to encompass all dimensions of the tuberculosis
response and enable not just measuring progress towards ending
tuberculosis, but also timely reviewing of results through government
and civil society accountability mechanisms at national and global
levels, as well as taking corrective actions.
WHO Member
States, the Stop TB Partnership, civil society, and other stakeholders
are working to make the most of the historic UN General Assembly
high-level meeting on tuberculosis in 2018. The WHO Ministerial
Conference in November, 2017, should provide ministers of health and
their heads of state with essential building blocks towards achieving
revolutionary commitments in 2018, and beyond.
We declare no competing interests.
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